EMPRESS Research Network
EMPRESS Research Network
Better Care for Septic Shock, More Lives Worth Living
About the Network
The EMPRESS Research Network is a multicenter, internationally collaborative clinical research network initiated by the Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, dedicated to improving the critical care of septic shock. The network’s core mission is to conduct high-quality multicenter clinical trials, while also providing methodological support, data governance, and investigator training.
Studies
EMPRESS StudyFirst study
Early Methylene Blue for Mortality Reduction in High-Dose VasoPREssor-Dependent Septic Shock — an investigator-initiated, multicenter, open-label, blinded-endpoint randomized controlled trial (566 patients; primary outcome: 28-day all-cause mortality; registration: ChiCTR2500112352).
Members
Steering Committee
Domestic
- Xiaobo Huang (Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital)
- Chun Pan (Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital)
- Jingchao Luo (Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital)
- Mei Meng (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine)
- Yongpo Jiang (Taizhou Hospital of Zhejiang Province)
- Xi Guo (Qilu Hospital of Shandong University, Third Campus)
International
- Minghao Luo (United Kingdom)
- Jean-Louis Teboul (France · Université Paris-Saclay)
- Glenn Hernández (Chile · Pontificia Universidad Católica de Chile)
- Miguel Ibarra-Estrada (Mexico · Universidad de Guadalajara)
- Eduardo Kattan (Chile · Pontificia Universidad Católica de Chile)
Coordinating Committee
- Jingchao Luo (Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital)
- Sen Lu (Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital)
- Jian Song (Shanghai Fourth People’s Hospital)
Data Safety Monitoring Board
- Ignacio Martin-Loeches (Ireland · St James’s Hospital / Trinity College Dublin · Chair)
- Longxiang Su (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences)
- Xiaobo Yang (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan)
Participating Centers
The EMPRESS study is conducted at more than 50 tertiary hospital centers across China (emergency, respiratory, medical, surgical, and other ICUs). The list of participating centers will be published here once confirmed by the Coordinating Committee.
Latest News
- 2026-11-0682 patients enrolled; approximately half of the study sites initiatedOngoing
- 2026-07-18DSMB Charter releasedReleased
- 2026-04-07Patient enrollment officially initiatedOngoing
- 2026-01-24Study protocol published (PMID: 41580807)Published
- 2025-11-20Protocol submitted to Scand J Trauma Resusc Emerg MedDone
- 2025-11-12Registered with the Chinese Clinical Trial Registry (ChiCTR2500112352)Done
- 2025-08-20Central ethics committee approval (No. 2025-583)Done